Sildenafil generic is a popular medicine that is utilized by men in order to help them treat pulmonary arterial hypertension and erectile dysfunction. The effectiveness of sildenafil generic when it comes to the treatment of women’s sexual dysfunction has not been studied thoroughly.
Sildenafil generic simply works by stopping the effects of an enzyme called cGMP-specific PDE5 (phosphodiesterase type 5) which is responsible for the degradation of cyclic GMP. Cyclic GMP (cGMP) is responsible for the regulation of smooth blood flow into the penile shaft.
Sildenafil generic was initially discovered by Nicholas Terrett, David Brown and Andrew Bell, all Pfizer scientists. Ever since sildenafil generic has become available commercially in the year 1998, it has been known as the most common treatment for erectile dysfunction. Other PDE5 inhibitors aside from sildenafil generic include vardenafil, tadalafil, and avanafil.
The first indication of sildenafil generic is for the treatment of erectile dysfunction in men, which is a man’s inability or failure to obtain an erection adequate enough to fulfill sexual satisfaction for the opposite sex. Sildenafil generic is now a standard treatment for erectile dysfunction in men, even those who also happen to have diabetes mellitus.
Aside from erectile dysfunction in men, sildenafil generic has been proven to be also very effective in cases of pulmonary arterial hypertension. The action of sildenafil generic is that it significantly relaxes the arterial wall, which then results to the minimized pulmonary arterial pressure and resistance. This then leads to the reduction of the heart’s (specifically the right ventricle) workload, thereby improving the symptoms of men who are suffering from right-sided heart failure. Due to the fact that PDE5 is mainly found within the smooth muscles arterial walls of the penis and lungs, sildenafil generic works within these places selectively without incurring vasodilation in other parts of the body. Should you be asked to take sildenafil generic mainly for pulmonary hypertension, the brand name would be Revatio.
Those who are using antidepressants may most likely experience some degree of sexual dysfunction, either as an effect of their treatment or because of their current illness. Studies made in 2003 have shown that the intake of sildenafil generic in this case have improved the erectile dysfunction in men who experience such situations.
Sildenafil generic can be somewhat helpful for the treatment and prevention of pulmonary edema of high-altitude origin. One such example would be the mountain climbers who experience altitude sickness – they are good candidates to take sildenafil generic should they ever get high-altitude pulmonary edema during their hike.
The most common side effects noted about sildenafil generic include flushing of the skin, heart burn, and mild to moderate headaches. If you have some kind of cardiovascular disorders, then you are duly cautioned if you are going to take sildenafil generic. Extremely rare but rather serious kinds of side effects include hearing loss of sudden onset nature as well as priapism, the medical term for abnormally prolonged erection, which can potentially result to permanent penile damage. Sildenafil generic must not be used by those who are currently taking nitrate medications such as nitroglycerin since both medicines can cause a dramatic and possibly deadly drop in one’s blood pressure.