When a man experiences erectile dysfunction, even if he is perfectly healthy all his life, he will surely succumb to emotional turmoil due to this embarrassing condition. Furthermore, when negative emotions are a constant factor in his everyday life, in the end, that man’s negative feelings will likely trigger a worsened state of erectile dysfunction problems.
Naturally, erection of the penis begins with sexual stimulation. It can either occur via tactile stimulation (such as touching or stroking the penis), or via mental stimulation (such as thinking about sexual fantasies). When sexual stimulation is being done, this creates electrical impulses that travel through the nerves which are then linked to the penis, causing such nerves to emit a substance known as nitric oxide. Nitric oxide is responsible for boosting up the production of cyclic GMP (cGMP) in the smooth muscle cells of the penile corpora cavernosa. The cGMP shall relax the corpora cavernosa smooth muscles, which then lets the blood to flow rapidly into the penile shaft, filling up the corpora cavernosa, expanding the penis, making it firm and erect. Unfortunately, as long as an enzyme known as phosphodiesterase type 5 (PDE5) destroys and decreases the amount of cGMP levels in the corpora cavernosa, difficulty with erection or no erection will occur.
Thanks to the advancements in health, science and technology, men can now look into different methods of treatment for their erectile dysfunction problems. As of now, there are medications which are specially formulated to treat erectile dysfunction, and they are called PDE5 inhibitors. These inhibit or stop PDE5 from manifesting inside a man’s body system, thereby letting them have the chance to acquire a firm erection good enough to undergo a successful sexual encounter. There are a handful of PDE5 inhibitors available in the market right now, and each of them has their pros and cons. Men tend to buy avanafil (brand name is Stendra) and try it out for themselves as it’s the newest one out in the market and it has proven itself to be safe and effective for most users.
Unlike other PDE5 inhibitors such as tadalafil, sildenafil, and vardenafil, men end up choosing to buy avanafil because it has a faster onset of action. Since it can be absorbed quickly by the body, it can reach its maximum concentration in a matter of 30 to 45 minutes. According to a study done on avanafil, around two-thirds of those who used it were able to successfully engage in sex in as little as 15 minutes – no wonder men are overjoyed to finally be able to buy avanafil and successfully get rid of their ED problem!
If you are going to buy avanafil, take note that it is available in 50, 100, and 200-mg tablets. It can be taken with or without food, which is totally convenient especially for those who like to eat occasionally throughout the day. Remember that if you are prescribed to buy avanafil and use it for your ED, never take more than once per day. If you carefully follow the advice of your physician regarding ED treatment with avanafil and you understand the precautions, warnings and contraindications on it, then you shall be well on your way to an ED-free life. Do not be discouraged if you buy avanafil and it turns out it does not work for you, as you may need a higher dose or another type of treatment, depending on what your physician decides on.
In case you aren’t aware of it, avanafil has been approved by the FDA for the treatment of erectile dysfunction on April 27, 2012. On June 21, 2013, it was also approved by EMA. There are actually two brand names that you ought to know before you buy avanafil, and those are Stendra and Spedra. Both of these were developed by Vivus Inc.